Treatment of Osteochondral Lesions of the Talus With Matrix-induced Autologous Chondrocyte Implantation (MACI)

Abstract

An osteochondral lesion of the talus is a common injury often resulting from an ankle fracture or ankle sprain. The role of nonoperative management is limited given the diminished healing capacity of these lesions. Among the available surgical options are cell-based techniques, which aim to regenerate hyaline-like articular cartilage. Matrix-induced autologous chondrocyte implantation is one such promising technique that has been validated as an effective and durable treatment option. This article reviews the matrix-induced autologous chondrocyte implantation technique and the evidence supporting its use.