Treatment of Oral Florid Papillomatosis with Systemic Administration of Photocarcinorin: An Effective Photodynamic Therapy

Abstract

To evaluate the safety and effect of systemic administration of photosensitizer Photocarcinorin (PsD-007) in the treatment of oral florid papillomatosis (OFP). OFP is a rare and refractory disease characterized by multiple papillomatous lesions. The outcomes of many methods for OFP are not satisfactory. Photosensitizer Photocarcinorin (5 mg/kg) was intravenously injected into a 59-year-old woman with widespread OFP, and the lesions were irradiated for 10 min by using a 635-nm laser beam of 177 mW/cm(2) intensity and 106.2 J/cm(2) energy density. The therapy was performed once a month for 3 months in total. After three courses, the small lesions disappeared, and the larger ones were reduced by ≥80%. The adverse effects were minimal. Systemic PDT is an effective and successful treatment modality for OFP, especially in elderly patients.