Treatment of obstructive jaundice by percutaneous biliary puncture combined with intensity modulated radiation therapy in the advanced cancer

Abstract

Objective To evaluate the efficacy of advanced cancer treatment of obstructive jaundice by percutaneous biliary puncture and intensity modulated radiation therapy.Methods Nineteen patients with advanced cancer of obstructive jaundice were treated by skin biliary puncture combined with intensity modulated radiation therapy.Results In 19 patients evaluated by the WHO criteria,2 cases (10.5 ％) had complete response (CR),15 cases (78.9 ％) had partial response (PR),while 1 case (5.3 ％) had stable disease (SD) and 1 case (5.3 ％) got progressive disease (PD).Jaundice relieve rate was 94.7 ％ (18/19),6,8,12 months survival rates were 78.9 ％ (15/19),47.4 ％ (9/19),15.8 ％ (3/19),and the median overall survival time was 10 months.Conclusion Percutaneous biliary puncture combined with intensity modulated radiation therapy is well effective for patients with advanced cancer of obstructive jaundice,related toxicities are tolerable.These results indicate that further clinical study is of great worth. Key words: Biliary puncture; Intensity modulated radiation therapy; Cancer; Obstructive jaundice