Abstract
Introduction Young myasthenic women manifest fluctuations in strength through various phases of the menstrual cycle. Typically, there is an exacerbation of weakness in the preovulatory stage, specifically in the five to seven days preceding the onset of menses, with a more accentuated depression of strength in the immediate premenstruum, often requiring increased doses of anticholinesterase drugs. 1 As menstrual flow is initiated, gradual recovery ensues and is maintained through and beyond the next ovulation. In a recent communication, 2 such variation has been linked to alterations in electrolyte balance due to the influence of progestational and mineralocorticoid hormones upon ionic flux across cell membranes. Experimentally, in myasthenic patients, the administration of progesterone intramuscularly was initially marked by a natriuresis without change in muscular strength. The sodium loss was then followed by sodium retention and an increased urinary excretion of aldosterone, the potent sodium-retaining hormone, which persisted after progesterone withdrawal; both
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
