Abstract
A model of immune complex glomerulonephritis (ICGN) produced in mice by the daily injection of apoferritin was employed to study the effect of treatment with various doses of prostaglandin E 2 (PGE 2) on glomerular damage, immune complex deposition, proteinuria, and serum anti-apoferritin antibody. Administration of PGE 2, 200 μg twice daily, resulted in a significant decrease in glomerular damage and immune complex deposition, prevented the development of proteinuria, and significantly reduced serum levels of anti-apopferritin antibody. PGE 2, 100 μg twice daily, resulted in a decrease in immune complex deposition as assessed by immunofluorescence microscopy, but this dosage did not significantly alter glomerular damage, proteinuria, or antibody levels. PGE 2 dosages of 50 and 25 μg twice daily had no effect on any of these parameters. The protective effect of PGE 2 on the development of ICGN occurred only at dosages that were associated with decreased anti-apoferritin antibody.
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