Abstract
Hair loss (alopecia) is a common problem for people. The dermal papilla is the key signaling center that regulates hair growth and it engage in crosstalk with the microenvironment, including Wnt signaling and stem cells. In this study, we explored the effects of bone marrow mesenchymal stem cell overexpression of Wnt1a on mouse hair follicle regeneration. Wnt-CM accelerated hair follicle progression from telogen to anagen and enhanced the ALP expression in the DP area. Moreover, the hair induction-related genes were upregulated, as demonstrated by qRT-PCR. Wnt-CM treatment restored and increased DP cell expression of genes downregulated by dihydrotestosterone treatment, as demonstrated by qRT-PCR assays. Our study reveals that BM-MSC-generated Wnt1a promotes the DP's ability to induce hair cycling and regeneration.
Highlights
Hair loss is a common problem for people
dermal papilla (DP) cells manage hair follicle cycling through secreted signaling factors
Human hair follicles affected by androgenic alopecia contain a largely intact population of hair follicle stem cells and a primary defect in DP signaling, resulting in hair anagen momentum being unable to start
Summary
Hair loss (alopecia) is a common problem for people. The dermal papilla is the key signaling center that regulates hair growth and it engage in crosstalk with the microenvironment, including Wnt signaling and stem cells. The androgen activator dihydrotestosterone (DHT), induced increased dickkopf 1 (Dkk-1) overexpression and decreased lymphoid enhancer factor-l (Lef-1) expression in cultured DP cells, which can cause apoptosis of follicular keratinocytes in co-cultured systems[6,7] These results are similar to the phenotype observed in AGA patients, where the hair follicle cycle is gradually interrupted during telogen phase, and terminal scalp hairs are gradually replaced by smaller hairs[8]. MSCs enhance wound healing and promote hair follicle regeneration through the differentiation or release of growth factors when injected in the wound bed in excisional wound splinting models[19]. It is unclear whether MSCs interact with DP cells to triggers hair regeneration
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