Abstract

A review and meta-analysis of therapy trials for menstrual-related migraine headache (MRM) and evidence-based recommendations for acute and short-term preventive treatment are reported from Toronto Western Hospital, ON, Canada.

Highlights

  • The clinical characteristics of paroxysmal hemicrania (PH) are reported in a series of 31 patients, ages 5-68 years, identified and followed prospectively at the National Hospital and the Hospital for Sick Children, Great Ormond Street, London, UK from May 1995 to January 2007

  • A review and meta-analysis of therapy trials for menstrual-related migraine headache (MRM) and evidence-based recommendations for acute and short-term preventive treatment are reported from Toronto Western Hospital, ON, Canada

  • In 23 children, aged 8 to 16 years, a randomized placebo-controlled, crossover trial of oral sumatriptan in Finland showed no significant differences in pain relief, 13 preferred sumatriptan. (Hamalainen ML et al Neurology 1997;48:1100-1103)

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Summary

Introduction

The clinical characteristics of paroxysmal hemicrania (PH) are reported in a series of 31 patients, ages 5-68 years (mean age 37), identified and followed prospectively at the National Hospital and the Hospital for Sick Children, Great Ormond Street, London, UK from May 1995 to January 2007. A review and meta-analysis of therapy trials for menstrual-related migraine headache (MRM) and evidence-based recommendations for acute and short-term preventive treatment are reported from Toronto Western Hospital, ON, Canada. Doubleblind, randomized controlled trials of medications for relief or prevention of MRM were included in the guideline. For 9 acute treatment trials that met inclusion criteria, outcome considered was pain response and pain-free response at 2 hours.

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