Abstract
ABSTRACT Two cases of malignant exophthalmos refractory to the usual medical and roentgenologic therapy were treated by implantation of the pituitary with radioyttrium (Y90). In both cases prompt and marked improvement of the ocular symptomatology occurred, in association with normalization of thyroid function. These results persisted in one case for at least sixteen months after the implantation; the other case was followed for only one month. No adrenocortical deficiency was observed. This effect of implantation of Y90 is interpreted as due to selective radiobiologic inhibition of the hyperactive pituitary cells which produce the thyrotropic hormone.
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