Abstract
Successful treatment of PP by daily subcutaneous (SC) administration of the LH-RH agonist D-Trp-6-LH-RH (Trp6) was reported (Kauli et al., ESPE 1983). After demonstration of its efficiency and innocuity in dogs, a long acting preparation designed for releasing continuously 100 μg Trp6 per 24 h, was given intramuscularly to 3 boys and 3 girls with PP, aged 3 to 8 years. 3 mg Trp6 were injected every 28 days, cyproterone acetate being associated during the first week. In boys testosterone levels (ng/ml) decreased from 2.2-5 to 0.1-0.2 within 2 months. Testis volume was unaffected in 1, decreased slighty in 2. In girls estradiol levels (pg/ml) decreased from 40-100 to 0-40 within 2 months and in a menstruating girl genital bleeding desappeared after 1 month. Breast enlargement was reduced in all. In all children, the gonadotropin responses to LH-RH were suppressed and the inhibition of gonadal secretion persisted after 6 months of treatment. The data demonstrate the ability of long acting Trp6 to suppress gonadal secretion by a monthly injection in children with PP.
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