Treatment of ligneous conjunctivits with subconjunctival fresh frozen plasma (ffp): about three severe cases

Abstract

AbstractPurpose Ligneous conjunctivitis is a rare type of chronic membranous conjunctivitis. It is inherited as an autosomal recessive disorder, with low plasminogen levels reported in both homozygous and heterozygous individualsMethods we describe the clinical features and response to subconjunctival FRESH FROZEN PLASMA (FFP) in three patients with severe ligneous conjunctivitis with a mean follow‐up of 12 months, among 15 patients followed in our department for the past 10 years.Results All our cases had bilateral ocular involvement except. They were all treated with subconjunctival injection of FFP after resection of the membranes. Topical heparin and rimexolone application was continued 1 month after surgery. As the case 2 presented a corneal perforation during the course of the disease, he was also treated with multiple inlay amniotic membrane graft.Conclusion FFP shortens the treatment period, reduces the probability of mid‐term recurrences and is a good alternative to a long‐term topical treatment with Heparin and steroid.