Abstract
BackgroundCardiac hypertrophy induced by pressure overload is one of the important causes of heart failure and sudden cardiac death. At present, there are few studies on the outcome of left ventricular hypertrophy and left ventricular function after complete pressure load removal.ObjectiveThis study aims to better simulate the changes of left ventricular structure and function during the process of left ventricular pressure overload and deloading, and to explore the application of echocardiography in it.MethodsIn this study, healthy male (BALB/C) mice were used as research objects to establish an ascending aorta constriction model, to carry out echocardiographic and hemodynamic examinations, to establish an ascending aorta deconstriction model in mice, and to carry out echocardiographic and hemodynamic examinations.ResultsCompared with the sham operation group, the left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), interventricular septal (IVS), and left ventricular posterior wall (LVPW) in the constriction operation group were significantly increased (P=.02, P=.02, P=.02, and P=.02, respectively). LVESD, LVEDD, IVS, and LVPW in the early and late constriction groups were significantly decreased, and the degree of decrease in the early group was greater than that in the late group; compared with the sham operation group, left ventricular diastolic pressure in the constriction operation group increased significantly at 9 and 15 weeks after operation (P=.03). Left ventricular systolic pressure at 15 weeks after operation decreased to a certain extent but was higher than that of the sham operation group (P=.02). The maximal rate of the increase of left ventricular pressure at 3 weeks, 9 weeks, and 15 weeks after operation decreased significantly (P=.03, P=.02, and P=.02, respectively).ConclusionsIn this study, the ascending aorta coarctation model and descending aorta coarctation model were successfully established, which verifies the value of echocardiography information data monitoring in the treatment of left ventricular circulation disorders and the evaluation of surgical treatment.
Highlights
The diastolic process of the heart is an important part of the cardiac cycle
It is necessary to establish an ideal left ventricular hypertrophy model and its reversal model, and to explore the characteristics of left ventricular structure and function during the process of left ventricular pressure overload-unloading through effective diagnostic means
Compared with 9 weeks after operation, left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) in mice increased significantly at 15 weeks after the operation, and the difference was statistically significant (P=.03 and P=.03. respectively), suggesting that heart failure occurs in mice
Summary
The diastolic process of the heart is an important part of the cardiac cycle. If abnormal physiological function occurs in this part, it will lead to left ventricular diastolic dysfunction, which will lead to the decline of left ventricular compliance and relaxation, leading to heart disease. Hypertension and aortic stenosis account for a large proportion of adult heart disease in China. Their common characteristics are that they lead to left ventricular pressure overload and left ventricular http://medinform.jmir.org/2020/9/e19110/ XSLFO RenderX. The evaluation of left ventricular function is the most important index in the diagnosis of various cardiovascular diseases and the evaluation of drug treatment effect. It can predict whether patients have heart failure, and it plays an important role in the clinic [8]. There are few studies on the outcome of left ventricular hypertrophy and left ventricular function after complete pressure load removal
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