Treatment of knee osteoarthritis with combination of traumeel s and zeel t: review mozart clinical investigation

Abstract

Traditional treatment of osteoarthritis is focused on the symptoms’ decrease using pain-killers, nonsteroid anti-inflammatory drugs (NSAIDs), intraarticular corticosteroid injections, hyaluronic acid and so on. Nevertheless, such a therapy has some limitation due to the possible side effects and contraindications, especially in elderly people with concomitant diseases. Traumeel S consists of 14 components with vegetal and mineral origins, that determine its anti-inflammatory, anti-exudative, anesthetic, restorative and immune-modeling action. Zeel T provides chondroprotective, anti-inflammatory, anesthetic effects that promotes restoration of metabolic and reparative processes in joint cartilage. Goal: to expose the results of multicenter randomized placebo-control double-blind investigation MOZArT («Management of Оsteoarthritis of the Knee with Zeel and Traumeel Injections») to evaluate the efficacy and safety of the intraarticular injections of Traumeel S and Zeel T in comparison with placebo. The methods: 232 patients from 24 centers in USA were involved in the investigation. Patients (119) from the main group took the injection of Traumeel S and Zeel T, 113 participants from control group – physiological solution as a placebo. Three injection of every remedy were carried out with 1-week interval between the injections. WOMAC A scale was used to assess the results. Results: under the conditions of Traumeel S and Zeel T usage significant reducing of pain by 60 % according to WOMAC A scale was observed after 2nd injection and during the following 12 weeks. The effect of mentioned combined therapy was compared with the results of intra-articular corticosteroid and hyaluronic acid injection and peroral diclofenac. Safety profiles of Traumeel S and Zeel T were more optimal in comparison with peroral NSAIDs, without any risk from cardiac-vascular and gastro-intestinal systems.