Treatment of Kaposi’s Sarcoma by Combination of Zinc Sulfate and Propranolol

Khalifa E Sharquie,Adil A Noaimi

doi:10.4236/jcdsa.2018.84026

Khalifa E Sharquie, Adil A Noaimi

Open Access

https://doi.org/10.4236/jcdsa.2018.84026

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Abstract

Kaposi’s sarcoma (KS) in Iraq has been reported as sporadic cases of elderly of Iraqi population but after exposure to depleted uranium radiation in early 1991, the frequency of the disease is increasing appearing in younger age with more wide spread and aggressive in nature. There is no satisfactory oral treatment to control this disease. The aim of the present work is to record a new regime of therapy using oral zinc sulfate and oral propanolol. Four patients with wide spread Kaposi’s sarcoma (KS) were treated with oral and topical zinc sulfate solution and oral propranolol. The duration of treatment was between 6 - 12 months and the response started few weeks and was obvious after one month. Most old lesions were resolved leaving post inflammatory hyperpigmentation and few lesions appeared during course of treatment.

Highlights

Kaposi’s sarcoma (KS) is a vascular neoplasm with multicentric cutanenous and extracutaneous involvements
Kaposi’s sarcoma (KS) in Iraq has been reported as sporadic cases of elderly of Iraqi population but after exposure to depleted uranium radiation in early 1991, the frequency of the disease is increasing appearing in younger age with more wide spread and aggressive in nature
Kaposi’s sarcoma in Iraq has been sporadic disease of elderly [3] but after American attack and depleted uranium radiation exposure in early 1991, the incidence of the disease is increasing and its onset observed at younger age, more wide spread and aggressive with more morbidity and mortality

Summary

Introduction

Kaposi’s sarcoma (KS) is a vascular neoplasm with multicentric cutanenous and extracutaneous involvements. It is considered as a reactive hyperplasia but not than a neoplasm. Despite its name, it is no more classified as a sarcoma and it has prominent vascular growth and neovascularisation [1]. Kaposi’s sarcoma in Iraq has been sporadic disease of elderly [3] but after American attack and depleted uranium radiation exposure in early 1991, the incidence of the disease is increasing and its onset observed at younger age, more wide spread and aggressive with more morbidity and mortality. All patients are negative for AIDS apart from few cases as a result of contamination of blood transfusion [4]

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