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Abstract
The use of malaria as a therapeutic agent in epilepsy was suggested by the known beneficial effects of other specific infections in this disorder. The earliest observation was probably that of Plato, who found that lepers were free from convulsions. A “tendency to respite which is sometimes temporarily induced in the course of the confirmed disease” (by febrile infections) is noted by Aldren Turner (1). Hamilton (2) found that of 11 cases who contracted typhoid 9 showed distinct temporary improvement, and 1 of these was free from seizures for four years. Maisonneuve and Gerard (3) reported cases of epilepsy whose seizures ceased altogether during 2 attacks of intermittent fever.
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