Abstract
The treatment of hypogonadism in men is of great interest to both patients and providers. There are a number of testosterone formulations currently available and several additional formulations under development. In addition, there are some lesser-used alternative therapies for the management of male hypogonadism, which may have advantages for certain patient groups. The future of hypogonadism therapy may lie in the development of selective androgen receptor modulators that allow the benefits of androgens whilst minimizing unwanted side effects.
Highlights
The Endocrine Society Clinical Practice Guideline defines male hypogonadism as “a clinical syndrome that results from failure of the testes to produce physiological levels of testosterone due to disruption of one or more levels of the hypothalamic-pituitarytesticular axis”[1]
Given that testosterone concentrations decline with age[2,3] and the increasing awareness of the signs and symptoms of hypogonadism, prescriptions for testosterone therapy have increased significantly in the last several years[4]
Risks and benefits of testosterone therapy For men with symptomatic hypogonadism, there are a number of potential clinical benefits with testosterone replacement therapy, including improvements in libido, erectile function, muscle strength and body composition, mood, and cognition[1]
Summary
F1000 Faculty Reviews are written by members of the prestigious F1000 Faculty. They are commissioned and are peer reviewed before publication to ensure that the final, published version is comprehensive and accessible. The reviewers who approved the final version are listed with their names and affiliations. Any comments on the article can be found at the end of the article
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