Abstract
Aim: To determine the association of interleukin-28b- RS12980275 with response to treatment with interferon α-2b & ribavirin in chronic hepatitis c patients Methodology: A case control study was designed that includes219 HCV patients treated with INF and Ribavirin. Out of 219, 95 were males while 124 were females. They are classified into two groups. Those achieved sustained virological response (SVR) and those who did not sustained virological response (Non-SVR). All the demographics and biochemical data were recorded on a Performa that includes age, ALT and viral load. The data were analyzed using SPSS version 16.0. Results: Patients having IL28B-rs12980275 AG genotypes respond better to interferon and ribavirin treatment (p-value=0.01, OR=2.91). Furthermore, HWE was also calculated for both groups in which the responders do not corresponds to HWE (p-value= <0.001) while the non-responders were found to be consistent with HWE (p-value= 0.31). Conclusion: Polymorphism in IL28B (rs12980275) was found to be significantly associated (p-value = 0.009) with the treatment outcome in patient with hepatitis C receiving standard therapy regimen (Interferon + Ribavirin). Key words: Hepatitis C, polymorphism, Interferon
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
