Treatment of Heart Failure in Eight Cases with Hyperthyroidism by Saikokarhukotsuboleito

Abstract

Eight cases with heart failure in hyperthyroidism treated by Saikokarhukotsuboleito extract were reported. All patients, 2 males and 6 females aged 30-71, were diagnosed as hyper-thyroidism by physical findings, serum thyroid hormone assay and TRH test. Heart failure with various severity from edema of the legs to pulmonary edema occurred in 3 untreated patients and during antithyroid therapy with beta blockade in 5 patients. After administration of Saikokarhu-kotsuboleito extract with antithyroid drug and beta blockade in 5 patients, with only antithyroid drug in 2 patients and no other medications in 1 patient, all patients recovered from the heart failure in 3-21 days. These observations in hyperthyroidism suggest that in the classical indications for administration of Saikokarhukotsuboleito, “startle and confusion” and “talk in delirium” would be neuropsychotic states caused by adrenergic hyperactivity and “fullness in the chest”, “dysuria” and “heavy sen-sation in the whole body and difficulty to turn over or lie down” would be states caused by high output heart failure.