Abstract
Background—The study aims to assess the efficacy of a permethrin 54.5%-fipronil 6.1%-based spot-on solution in dogs naturally infested with Neotrombicula in an open-label controlled study. Methods—Ten naturally infested dogs received one drop per affected site on day (D) 0, and on D14, the rest of the pipette was applied on the skin between the shoulders. Five dogs served as sentinels. Parasite score (0–3), skin lesions (0–4), and investigator pruritus scale (0–4) were assessed on D0, D1, D14, and D28. Results—No treated dogs developed adverse reactions. Parasite score of sentinel dogs was maintained between 1.8 (D0, D1, and D28) and 2.2 (D14). In treated dogs, D0 parasite score was 2.4. It was significantly reduced from D1 (0.5; p < 0.002) to D28 (0.1; p < 0.002). The lesion score was 2.9 on D0 and D1; it was significantly reduced on D14 (0.6; p < 0.002) and D28 (0.1; p < 0.002). Similarly, investigator pruritus scale (D0, 2.2) scores significantly decreased on D14 (0.4; p < 0.004) and D28 (0.2; p < 0.002). Conclusions—The combination permethrin-fipronil appears to be well-tolerated, rapidly and durably effective in the control of localized canine harvest mite infestation.
Highlights
Harvest mites, known as chigger mites, are common skin parasites that are present worldwide.Harvest mites feed on small rodents, they are capable of feeding on humans and practically on all species of domestic animals, including birds [1,2,3,4]
The objective of the study is to evaluate the efficacy of a permethrin 54.5%-fipronil 6.1%-based spot-on solution (Effitix® ; Virbac, Carros, France) in dogs naturally infested with harvest mites
Exclusion criteria included (i) dogs with systemic illness or condition which could deteriorate during the study period, (ii) dogs with a known sensitivity to fipronil or permethrin, (iii) dogs having received an acaricide during the twelve weeks prior to inclusion
Summary
Harvest mites feed on small rodents, they are capable of feeding on humans and practically on all species of domestic animals, including birds [1,2,3,4]. They have a strong seasonal activity and are usually found in the highest numbers on hosts in late summer and autumn. They prefer chalky soils to clay and can be numerous on grassland, cornfields, heathland, and scrubby woodland [5]. The study aims to assess the efficacy of a permethrin 54.5%-fipronil 6.1%-based spot-on solution in dogs naturally infested with Neotrombicula in an open-label controlled study
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