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Abstract
Background: Melanocytes transplant for treatment of vitiligo is a common therapy using different surgical procedures. But there was no interest in repigmentation of grayness of hair in the treated vitiliginous area. Objective: To do melanocytes transplant from donor area into the recipient vitiliginous area with associated gray hair. Patient and Methods: This is a case interventional study was done in Department of Dermatology/Baghdad Teaching Hospital from February 2011-March 2012. Eleven patients were enrolled in this study, six males and five females with vitiligo in association of gray hair. Their ages ranged from 8 - 35 years with a mean ±SD of 20.90 ± 7.006. Melanocytes transplant in patients with vitiligo using needling micrografting technique for twelve patches and direct melanocytes transplant from normal donor area into vitiliginous recipient area by dermabrasion technique for eleven patches. Dressing was applied and patients were seen every two weeks for the first month and monthly for one year. Results: Repigmentation of the vitiliginous area was started after two weeks and was obvious at one month that progressed over time. The repigmentation of hair appeared usually after few months and was obvious after four months and the repigmentation of gray hair was quicker in patients with micrografting technique than those with dermabrasion technique. The mean rate of repigmentation was 18.3% at six months and 37.5% at twelve months in micrografting technique while the mean rate of repigmentation was 9.15% at six months and 18.55 at twelve months in dermabrasion technique. Conclusions: Direct transplant of melanocytes from normal donor area into recipient vitiliginous area with associated white hair is an effective procedure to induce repigmentation of gray hair.
Highlights
IntroductionVitiligo is a common autoimmune inflammatory disease where there is absence, deficiency or dysfunction of melanocytes [1,2,3,4].Melanocytes transplants by different procedures in patient with vitiligo are common procedures like: punch minigraft [5,6,7], suction blister epidermal grafting [8], and split thickness grafting [9,10] and non-cultured melanocytes grafting [11,12,13] and transplantation of cultured autologous melanocytes [14,15,16].But still no reports appeared in the literatures showing interest in repigmentation of gray hair in the treated vitiliginous area in patient with vitiligo.During our work doing melanocytes grafting by two techniques: the first one called melanocytes transplant in patients with vitiligo using needling micrografting technique [17] and the second one so called direct melanocytes transplant from normal donor area into vitiliginous recipient area by dermabrasion technique [18], we noticed repigmentation of the gray hair.So, the aim of the present work is to report eleven patients who had repigmentation of their associated gray hair.2
During our work doing melanocytes grafting by two techniques: the first one called melanocytes transplant in patients with vitiligo using needling micrografting technique [17] and the second one so called direct melanocytes transplant from normal donor area into vitiliginous recipient area by dermabrasion technique [18], we noticed repigmentation of the gray hair
We noticed that repigmentation of vitiligo skin started after one month while repigmentaand Dermabrasion Techniques tion of gray hair was obvious after four months
Summary
Vitiligo is a common autoimmune inflammatory disease where there is absence, deficiency or dysfunction of melanocytes [1,2,3,4].Melanocytes transplants by different procedures in patient with vitiligo are common procedures like: punch minigraft [5,6,7], suction blister epidermal grafting [8], and split thickness grafting [9,10] and non-cultured melanocytes grafting [11,12,13] and transplantation of cultured autologous melanocytes [14,15,16].But still no reports appeared in the literatures showing interest in repigmentation of gray hair in the treated vitiliginous area in patient with vitiligo.During our work doing melanocytes grafting by two techniques: the first one called melanocytes transplant in patients with vitiligo using needling micrografting technique [17] and the second one so called direct melanocytes transplant from normal donor area into vitiliginous recipient area by dermabrasion technique [18], we noticed repigmentation of the gray hair.So, the aim of the present work is to report eleven patients who had repigmentation of their associated gray hair.2. During our work doing melanocytes grafting by two techniques: the first one called melanocytes transplant in patients with vitiligo using needling micrografting technique [17] and the second one so called direct melanocytes transplant from normal donor area into vitiliginous recipient area by dermabrasion technique [18], we noticed repigmentation of the gray hair. Objective: To do melanocytes transplant from donor area into the recipient vitiliginous area with associated gray hair. Melanocytes transplant in patients with vitiligo using needling micrografting technique for twelve patches and direct melanocytes transplant from normal donor area into vitiliginous recipient area by dermabrasion technique for eleven patches. Conclusions: Direct transplant of melanocytes from normal donor area into recipient vitiliginous area with associated white hair is an effective procedure to induce repigmentation of gray hair
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