Treatment of Generalized Granuloma Annulare With Dapsone

Abstract

To the Editor.— We describe here two patients with generalized granuloma annulare who responded favorably to treatment with dapsone. Report of Cases.—Case 1.— A 16-year-old girl came to us in April 1978 with a two-month history of a progressive asymptomatic papular eruption on her thighs, buttocks, and hips. She was in good health and denied recent illnesses or the ingestion of medications. The eruption consisted of multiple erythematous to slightly yellow, dome-shaped papules ranging in size from 0.5 to 1 cm. Initially, no lesions demonstrated central clearing. A skin biopsy specimen demonstrated histologic changes consistent with granuloma annulare. The patient returned one month later because more lesions had appeared on her arms, legs, and in the original areas. Several lesions were now 1.5 to 2 cm in size and demonstrated central clearing. Findings from laboratory studies, which included a 12-factor automated chemical analysis, complete blood cell (CBC) count,