Abstract
INTRODUCTIONSINCE pleuropneumonia-like organisms (PPLO) are implicated as the cause of chronic respiratory disease (CRD) of chickens, specific drug action against these organisms should measurably aid in the control of naturally occurring CRD. The efficacy of tylosin, a new antibiotic, in the control of an experimental PPLO infection in young chickens has been studied using the previously described infection system of Ose et al. (1960).MATERIALS AND METHODSProperties of tylosin—The physical and chemical characteristics of tylosin have been described in detail by Hamill et al. (1960). The antibiotic has a wide margin of safety and is relatively non-irritating on injection in chickens, turkeys and mammals, or on dust inhalation by chickens. Tylosin in aqueous solution in the pH range of 4.0 to 9.0 is stable for at least one month at room temperature. The lactate and tartrate salts of tylosin are soluble in water in amounts greater than …
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