Abstract
Metastases outside the neck occur in 10 to 15% of patients with differentiated thyroid cancer (1). Almost half of them are present initially. The lungs and bones are the most frequent locations. Metastases in the brain, liver or skin tend to appear late in patients who already have multiple bone or lung metastases. In patients with metastatic disease, the main prognostic factor for cure and for survival is the treatment of metastases at a stage when they are not visible on X-rays (2). Their early detection is based on the combined use of serum thyroglobulin (Tg) measurement and total body 1311 scan (1311-TBS).
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