Treatment of different phenotypes of chronic obstructive pulmonary disease

Abstract

The aim of the study was to investigate COPD phenotypes in order to improve treatment efficacy of occupational COPD and comorbidity of COPD and hypertension.Methods. This singlecenter observational study involved 97 patients with occupational COPD (according to GOLD 2011 criteria) exposed to chemicals (n = 42) or dusts (n = 55) and 103 patients with of COPD and hypertension (according to ESH/ESC 2013 criteria). Comparison groups included patients with 73 smokers with COPD and 99 patients with COPD without hypertension. Phenotypic features of occupational COPD caused by different workrelated factors and comorbidity of COPD and hypertension were described. The obtained results underlie the treatment programs for each group. A singlecenter openlabel comparative study was conducted to evaluate the efficacy of this approach.Results. Beclometasone/formoterol combination and tiotropium were used for therapy of COPD related to chemical exposure; indacaterol, glycopyrronium and budesonide were used for therapy of dustrelated COPD. Patients with comorbidity of COPD and hypertension were treated with budesonide/formoterol combination and aclidinium. Coprimary endpoints were exacerbation rate and change of FEV1pred. Treatment with beclometasone/formoterol and tiotropium decreased the exacerbation rate, increased FEV1, improved symptoms, and decreased pulmonary hypertension in patients with COPD related to chemical exposure. Treatment with indacaterol, glycopyrronium and budesonide decreased the exacerbation rate, increased FEV1, improved symptoms, and decreased pulmonary hypertension in patients with dustrelated COPD. Treatment with budesonide/formoterol and aclidinium improved lung function, decreased pulmonary hypertension and improved symptoms in patients with comorbidity of COPD and hypertension.Conclusion. Different risk factors of COPD could be considered as markers of therapeutic response.