Abstract

Diarrhoea is a major cause of morbidity and mortality in rural communities in Africa, particularly in children under the age of five. This calls for the development of cost effective alternative strategies such as the use of herbal drugs in the treatment of diarrhoea in these communities. Expenses associated with the use of orthodox medicines have generated renewed interest and reliance on indigenous medicinal plants in the treatment and management of diarrhoeal infections in rural communities. The properties of many phenolic constituents of medicinal plants such as their ability to inhibit enteropooling and delay gastrointestinal transit are very useful in the control of diarrhoea, but problems such as scarcity of valuable medicinal plants, lack of standardization of methods of preparation, poor storage conditions and incertitude in some traditional health practitioners are issues that affect the efficacy and the practice of traditional medicine in rural African communities. This review appraises the current strategies used in the treatment of diarrhoea according to the Western orthodox and indigenous African health-care systems and points out major areas that could be targeted by health-promotion efforts as a means to improve management and alleviate suffering associated with diarrhoea in rural areas of the developing world. Community education and research with indigenous knowledge holders on ways to maximise the medicinal potentials in indigenous plants could improve diarrhoea management in African rural communities.

Highlights

  • Diarrhoea is the frequent passage of unformed, loose or watery stools, usually three or more times in 24 hours [1,2]

  • This review examines useful medicinal plants employed in the control of diarrhoea in rural African communities and points out major areas that could be targeted by health-promotion efforts as a means to improve management and alleviate the suffering associated with this disease

  • The plant material should only be powdered when needed and stability studies carried out at specific time intervals to ascertain quality [107]. It is critically important for anti-diarrhoeal agents to be readily available and attainable in rural communities of the developing world, in order to address the high morbidity and mortality among children, and for families to be educated on standard methods of application

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Summary

Introduction

Diarrhoea is the frequent passage of unformed, loose or watery stools, usually three or more times in 24 hours [1,2]. As a means of ensuring effective treatment clinicians have resorted to the use of combination therapies in the management of diarrhoeal diseases leading to increase pill burden and longer duration of therapy Considering that these therapies may still be ineffective and adverse effects may occur, and given the fact that hospitals may not be readily accessible in rural African communities, dependence on indigenous herbal medicines as remedies for diarrhoea is on the rise in these communities. Considering that indigenous medicine is one of the most commonly sought remedies for treating diarrhoea in many rural areas of the developing world, it becomes imperative to pursue measures to maximise the medicinal potential of indigenous plants Such measures would help alleviate undue suffering associated with the disease and reduce the number of lives lost. This review examines useful medicinal plants employed in the control of diarrhoea in rural African communities and points out major areas that could be targeted by health-promotion efforts as a means to improve management and alleviate the suffering associated with this disease

Aetiology of Diarrhoea
Diagnosis of Diarrhoea
Treatment Strategies
Anti-Motility and Anti-Secretory Agents
Antimicrobial Therapy
Treatment with Indigenous Herbal Medicines
Pharmaceutical Anti-Diarrhoeic Agents Isolated from Medicinal Plants
Plant Over-Exploitation
The Excessive Harvest of Certain Plant Parts
Lack of Standardization of Methods
Dosages and Quality Control of the Medicines
Packaging and Storage
Findings
Conclusions
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