Abstract
Background This meta-analysis was to evaluate the efficacy of autologous stem cell administration for the treatment of diabetic foot. Methods The electronic databases included PubMed, EMBASE, BIOSIS, Cochrane central, and Google Scholar internet, last updated on May 30, 2019. Evaluated outcomes included the rate of wound healing and amputation. Dichotomous outcomes were described as risk ratios (RR) with 95% confidence intervals (CIs). Statistical analysis was performed with RevMan 5.0 software and STATA 10.0 software. Results Eight randomized controlled trial (RCT) studies were included in this study. The meta-analysis showed a lower amputation (RR 0.25, 95% CI 0.11 to 0.54, I2 = 0) and a higher wound healing rate (RR 2.05, 95% CI 1.67 to 2.51, I2 = 4) in the cell therapy group compared with control. Conclusion This meta-analysis supports the effective role of stem cell therapy in promoting wound healing and decreasing rate of amputation in diabetic foot. In the future, more high quality and well-designed studies are need.
Highlights
Diabetic foot, a serious complication in type 2 diabetes, afflicts approximately 6% of people with diabetes worldwide [1]
Eight randomized controlled trial (RCT) involving 348 patients and 367 limbs were included in our study [11,12,13,14,15,16,17,18]
The study of Lu et al was divided into two groups treated with bone marrow mesenchymal stem cells (BMMSCs) or BMMNs, respectively, and the study of Kirana et al was divided into two groups treated with bone marrow mononuclear cells (BMMNCs) or bone marrow-enriched tissue repair cells (BMTRCs), respectively
Summary
A serious complication in type 2 diabetes, afflicts approximately 6% of people with diabetes worldwide [1]. In 2017, a meta-analysis by Guo et al reported the effect of autologous stem cell administration in the treatment of diabetic foot ulcer [5]. The authors stated that stem cell administration was significantly favorable for healing diabetic ulcers This meta-analysis was to evaluate the efficacy of autologous stem cell administration for the treatment of diabetic foot. The meta-analysis showed a lower amputation (RR 0.25, 95% CI 0.11 to 0.54, I2 = 0) and a higher wound healing rate (RR 2.05, 95% CI 1.67 to 2.51, I2 = 4) in the cell therapy group compared with control. This meta-analysis supports the effective role of stem cell therapy in promoting wound healing and decreasing rate of amputation in diabetic foot. More high quality and well-designed studies are need
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