Abstract
Diabetes is a well-recognized risk factor for the development of cardiovascular disease. In recent years, several new glucose-lowering drugs (GLD) have shown improvements in cardiovascular outcomes, renewing interest of cardiovascular specialists in diabetes management. Individual studies in the last 5 years have demonstrated the cardiovascular safety of certain dipeptidyl peptidase-4 inhibitors, glucagon-like peptide 1 agonists, and sodium glucose cotransporter 2 inhibitors. Recent meta-analyses have attempted to demonstrate class effects of these medications, but remain driven by several large studies. Other studies have used registry data to show improvements in cardiovascular outcomes in patients receiving new GLD compared with insulin therapy. The cardiovascular benefits of GLD are so attractive that these agents have been applied to patients without diabetes, though these studies have not borne a net clinical benefit in nondiabetic patients. An evolving body of literature now supports the safety profile of many new GLDs in patients at risk for cardiovascular disease. Several new agents have demonstrated improvements in cardiovascular outcomes and are now recommended as second-line agents after metformin in patients with cardiovascular disease. VIDEO ABSTRACT.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
