Abstract
BackgroundThe aim of the study was to test the effect of two treatments in cases of acute puerperal metritis (APM) and clinical metritis (CM).MethodsCows with APM and CM (n = 40)) were matched according to plasma fibrinogen levels (Fb) into three groups. Two negative control groups D (n = 11) and E (n = 17) were composed of healthy cows. The proportion of animals with APM and CM was similar within the groups. Treatment was started on the 3rd day postpartum (PP). In group A (n = 15), intramuscular (i.m.) administration of ceftiofur was used for five days in combination with flunixin for three days. Group B (n = 15) received i.m. administration of ceftiofur for five days followed by two injections of prostaglandin F2α, with an interval of 8 h, on the 8th day PP. Group C (n = 10) served as a control group with no treatment. The general health status, body temperature (BT) and vaginal discharge were evaluated daily. Endometrial biopsies for bacteriology were taken once a week for seven weeks PP. Blood samples for the analysis of acute phase proteins were collected once a week for six weeks PP. Samples for progesterone analysis were taken twice a week for seven weeks PP. Fertility performance data were recorded.ResultsThe area under the curve of BT was higher in group B than in group D cows (P < 0.05). No differences were found for vaginal discharge. There were no differences in bacterial growth, start of ovarian activity or serum amyloid-A or fibrinogen levels among the groups. The haptoglobin concentration was higher in the first and second weeks PP in group B compared with the other groups (P < 0.05). The number of days open was higher in group A than in both groups B and D (P < 0.05). The pregnancy rate after the first two services was higher (P < 0.05) in groups B and D than in groups A and C. The number of services per pregnancy was lower in group B than in group C (P < 0.05).ConclusionsRegardless of more severe uterine inflammation found in animals from group B, these cows showed the same fertility parameters as healthy animals.
Highlights
The aim of the study was to test the effect of two treatments in cases of acute puerperal metritis (APM) and clinical metritis (CM)
All cows were fed the same diet in the form of a total mixed ration (TMR)
One animal from group B was culled from the herd before the end of the sampling period because of polyarthritis and was excluded from the study
Summary
The aim of the study was to test the effect of two treatments in cases of acute puerperal metritis (APM) and clinical metritis (CM). Acute puerperal metritis (APM) and clinical metritis (CM) occur in the early postpartum (PP) period They constitute a widespread problem in dairy farming that causes high economic losses [1]. Regardless of the During normal uterine involution process after parturition a variety of aerobic and anaerobic bacteria, growing in the uterine lumen, are removed through a range of uterine defence mechanisms [2]. These mechanisms are effective in combination with good preventive measures, such as ensuring cows’ adequate immune status and the correct energy balance around calving, together with good hygiene. Otherwise, following contamination of the uterine lumen by such pathogens as Arcanobacterium
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