Treatment of Cutaneous Lesions with a Novel Erbium-Doped Yttrium Aluminum Garnet Laser with Micron Tips

Abstract

The water content of epidermis below the stratum corneum is more than 70%. The 2,940-nm wavelength is at the peak of water absorption, making it an ideal wavelength for ablation of skin. The purpose of this study was to determine the effectiveness and safety of a novel erbium-doped yttrium aluminum garnet (Er:YAG) laser with micron tips in the removal of cutaneous lesions. Fourteen subjects with various cutaneous lesions received a single treatment with an Er:YAG laser, using an average fluence of 104.7 J/cm² (range 99-314 J/cm²), a mean repetition rate of 11.7 Hz, and straight and curved tips with a 400- to 600-μm spot size. One subject received two treatments with a 1-month interval. The majority of subjects (80%, n = 12) did not require anesthesia. Clearance of 76% to 100% was obtained in 33% (n = 5) of subjects 1 month after treatment, 67% (n = 10) of subjects at 3 months, and 100% (n = 15) of subjects at 6 months. Investigators noted complete lesion clearance in all subjects 6 months after treatment. Ninety-three percent of subjects (n = 14) reported satisfaction with the procedure and its outcome. The 2,940-nm wavelength combined with small micron spot size tips provides safe and effective clearance of cutaneous lesions, even in hard-to-reach locations. HOYA-Con Bio supported study-related expenses.