Abstract
In twenty first century corona virus is considered as a big disaster. According to World Health Organization (WHO) the COVID 19 is becoming a pandemic in this month of March and now affected 203 countries. Scientists are endeavoring to discover drugs for its efficacious treatment. Multiple drug trails are going world-wild since there are no vaccines for this disease. Since there are no vaccines for this disease the best way to combat this virus is by social distancing of the host. In this regards we conduct a systematic review with a drug that can prevent a corona infection for the time being like Chloroquine, Glucocorticoids, Tocilizumab, Lopinavir/ritonavir, Corticosteroids, Ribavirin +/- interferon, Oseltamivir and baloxavir, Melatonin, Teicoplanin and other glycopeptides, Monoclonal or polyclonal antibodies and other therapies.
Highlights
The epidemic of Coronavirus Disease 2019 (COVID-19) first broke out in Wuhan in December 2019, and reached its peak in Wuhan in February 2020
In this regards we conduct a systematic review with a drug that can prevent a corona infection for the time being like Chloroquine, Glucocorticoids, Tocilizumab, Lopinavir/ritonavir, Corticosteroids, Ribavirin +/- interferon, Oseltamivir and baloxavir, Melatonin, Teicoplanin and other glycopeptides, Monoclonal or polyclonal antibodies and other therapies
The lack of significant disease improvement with IFN-I treatment in numerous studies can be explained by the mechanisms of inhibition of the IFN signaling pathway used by MERS-CoV and SARS-CoV (Severe Acute Respiratory Syndrome- Coronavirus), by the limited number of patients or animals used in the studies, or by the difficulty to decipher whether disease improvements were caused by IFN-I or the drugs used in combination with it
Summary
The epidemic of Coronavirus Disease 2019 (COVID-19) first broke out in Wuhan in December 2019, and reached its peak in Wuhan in February 2020. It became a major public health challenge for China, and evolved into a global pandemic in March 2020 [1]. In December 2019, a novel coronavirus (temporarily named severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) caused a cluster of pneumonia cases in Wuhan, China. The WHO, declared that the epidemic of COVID-19 had become a "global pandemic" As of this time there is no known specific, effective, proven, pharmacological treatment. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic.
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