Abstract
Six patients suffering from congenital hypoplastic anaemia and treated with prednisone are presented.Three of them responded well and showed reticulocytosis followed by increase of haemoglobin. Prednisone in a daily dosage of 15–20 mg. was effective while less seemed ineffective and higher doses did not give a better response. By giving prednisone intermittently marked growth retardation was avoided during observation periods of 4–13 years.The other three patients responded less well. It was not possible in these cases to elicit reticulocytosis regularly, and reticulocytosis was never followed by a corresponding increase of haemoglobin. One of these patients died from pneumonia at the age of 4 months. The other two have been treated for 4 and 5 years, respectively, with prednisone given intermittently, and with blood transfusions. Only moderate or mild growth retardation was observed.
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