Treatment of chronic urogenital infection in woman using the methods of extracorporeal blood correction

Abstract

Aim. To study of the effectiveness of treatment of patients with chronic urogenital infection by antibiotic therapy and extracorporeal immunotherapy. Methods. Clinical, microbiological, immunological and statistical methods were used. The main group consisted of 70 women with chronic urogenital infection previously treated with conventional treatment. Women received the extracorporeal antibiotic therapy and immunotherapy using moxifloxacin and metronidazole in combination with local therapy - suppositories with chlorhexidine, metronidazole and miconazole. For antibiotic and extracorporeal immunotherapy selected leukocyte cell suspension was incubated with an antibiotic and was stimulated by leukinferon and then was returned to the patient. In a control group patients received conventional drug treatments, ornidazole administered in conjunction with local therapy. When mixed infection was diagnosed josamycin additionally was administered. The diagnosis was verified by means of the polymerase chain reaction, bacteriological and microscopic methods. Results. The main complaints of the patients were excreta from the genital tract, itching, burning. The results of treatment were evaluated at 2 weeks, 1 and 2 months. After 2 weeks, in the main group more rapid regression of clinical manifestations and the improvement of the general state were registered, in the control group the symptoms persisted in more than 50% of women. After one month there were no complaints in the main group, while in the control group, the symptoms persisted in 30% of patients. After 2 months, patients of the main group had no complaints, but 0.4% had leukocytosis in the smear and marked growth of Trichomonas. In the control group excreta was maintained in 6.7%, positive culture on Trichomonas registered in 3.3% of patients. Conclusion. Our research indicates the clinical efficacy of extracorporeal antibiotic therapy and immunotherapy in the treatment of chronic urogenital infections compared with traditional methods, it promotes more rapid bacterial eradication and relief of the inflammatory process.