Abstract
Biochemical studies were made in Pronase-Porally administered cases of chronic sinusitis maxillaris to clarify the drug's healing mechanism which has been only partially reported. Of the various kinds of proteolytic enzymes those with powerful hydrolysis seem favorable for a pus-dissolving action in clinical use. In this report, Pronase-P is found to be most satisfactory, followed by a-chymotripsin and Varidase in descending order.In cases where responses to a single oral administration of Pronase-P were not seen, favorabe results were obtained with a combined administration of antibiotics.
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