Treatment of chronic obstructive pulmonary disease in clean-up workers of the Chornobyl NPP accident in the remote period after irradiation with additional 6 month prescription combination of ambroxol and essential phospholipids

Abstract

According to the results of the clinical and epidemiological studies in clean-up workers of Chernobyl NPP (ChNPP) accident in the remote period were detected the growth of morbidity of COPD with substantial features of pathomorphosis, that make difficulties for treatment. The aim: of the study was to determine the effectiveness of long-term administration (6 months) combination Ambroxol and Essential Phospholipids (EP) added to basic treatment in patients with moderate and severe COPD - clean-up workers of the ChNPP accident. Materials and methods: Studied 60 COPD patients before treatment and 1 year after from the beginning, who were randomly assigned to two groups: the first group of patients (32 persons) additionally was appointed long reception (6 months) combination Ambroxol (30 mg x 3 times per day) and EP (600 mg x 3 times per day), in the second group (28 people) patients received only basic therapy. The doses of radiation exposure were 25 – 500 mSv. Were studied clinical, functional characteristics, the number of exacerbations. Results and conclusions: Low response to the basic COPD therapy were shown by clean-up workers of the ChNPP accident, which is defined by the absence of significant changes in lung function tests. Additional appointments to the basic treatment of COPD combination of Ambroxol (30 mg x 3 times per day) and EP (600 mg x 3 times per day) within 6 months of the liquidators of the Chernobyl made it possible to reduce the frequency of exacerbations in 46.9% patients without significant improvement in lung function tests.