Abstract
Ocular inflammations such as uveitis and scleritis can lead to significant visual impairment if not treated properly. To limit potentially sight-threatening complications, good control of the inflammation in the acute phase is necessary. Corticosteroids have been the mainstay of ocular therapies for many years, but high doses of corticosteroids, which are required to maintain quiescence in severe uveitis, can be associated with many systemic and ocular complications. In order to limit steroid side-effects, classic immunosuppressant and immunobiologic agents have been widely used as steroid-sparing agents. In this review, we summarise the immunosuppressive drug therapy utilised in the treatment of ocular inflammatory diseases.
Highlights
Ocular inflammatory diseases, such as severe uveitis and scleritis, may require intense immunosuppressive therapy to control ocular inflammation and prevent irreversible visual impairment
We summarise the immunosuppressive drug therapy utilised in the treatment of ocular inflammatory diseases
The aim of this paper is to review recent ophthalmological literature concerning new treatment modalities for non-infectious uveitis and scleritis, and to offer a practical guide for internists and general practitioners
Summary
Ocular inflammations such as uveitis and scleritis can lead to significant visual impairment if not treated properly. To limit potentially sight-threatening complications, good control of the inflammation in the acute phase is necessary. Corticosteroids have been the mainstay of ocular therapies for many years, but high doses of corticosteroids, which are required to maintain quiescence in severe uveitis, can be associated with many systemic and ocular complications. In order to limit steroid side-effects, classic immunosuppressant and immunobiologic agents have been widely used as steroid-sparing agents. We summarise the immunosuppressive drug therapy utilised in the treatment of ocular inflammatory diseases
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