Treatment of chronic hepatitis C virus infection in children

Abstract

Hepatitis C virus (HCV) infection may occur in infants and children, although it is much less common than it is in adults. The main transmission routes include mother-to-infant transmission, use of HCV infected blood products, unsterile needles or syringes and other invasive procedures.The natural course of HCV infection in children is variable: some (20–40%) develop an acute resolving infection and spontaneous regression occurs in approximately one-third of infants of HCV infected mothers before 2 years of age. Approximately 60–80% of HCV infected children develop a chronic infection with varying degrees of activity and fibrosis, mostly mild during childhood. However, the potential risks of liver cirrhosis and hepatoma during later life are obvious.Interferon is the main agent used to treat HCV infection in children. The response to interferon at the end of 4–12 months of therapy ranges from 25–90%. A sustained response was found in 36–56% of children 6–36 months after the end of therapy. The duration of therapy is recommended to be 12 months. At the end of 3 months, an evaluation of the response is indicated in the majority of children, except those with thalassemia, in whom evaluation of response should be conducted at the end of 6 months of therapy.The benefit of other therapies, such as combination therapy with interferon and ribavirin in children with hepatitis C is currently under investigation.