Abstract
An experimental model is described in which the conditions of chronic urinary bladder infections in man are simulated. The model was used to test the efficiency of mechanically controlled intermittent instillation therapy administered for more than twenty hours. Antiseptic drugs of the preantibiotic era, nephrotoxic and neurotoxic antibiotics as well as nitrofurantoin were instilled. Three species of bacteria which are common urinary pathogens were used as infecting agents. The results demonstrate that the model chosen effectively simulates chronic urinary tract infection in man. The results of prolonged automatic intermittent instillation therapy warrant the application of this technique to the treatment of chronic cystitis in man.
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