Treatment of choroidal neovascularization associated with choroidal nevus

Abstract

Abstract Purpose Purpose:To evaluate safety and efficacy of different treatments of choroidal neovascularization (CNV) associated with choroidal nevus at the posterior pole. Methods Methods: Six patients affected by choriodal nevus complicated by CNV were treated with photodynamic therapy with verteporfin (PDT; 50 J/cm2, 83 seconds) (five cases), or intravitreal anti‐VEGF (bevacizumab, 1.25 mg) (one case). All patients underwent an ophthalmologic evaluation, including fluorescein and indocyanine green angiography, A‐and B scan ultrasonography and OCT at presentation and at each follow‐up examination. CNV was extrafoveal in all PDT treated cases, and a foveal serous detachment was detectable. CNV was subfoveal in the eye treated with anti‐VEGF. Results Results: Mean follow‐up was 15.5 months (range: 6 – 24). Visual acuity improved in four of the PDT treated cases and in the anti‐VEGF treated eye, while it remained unchanged in the remaining PDT treated lesion. In all eyes resolution of the foveal serous detachment was detectable. In all PDT treated eyes a single treatment was performed with no recurrence during follow‐up. Meanwhile anti‐VEGF was repeated after three months for CNV recurrence. Conclusion Conclusions: PDT and anti‐VEGF seem both effective in the treatment of CNV secondary to choroidal nevus but a larger study is required to evaluate long‐term efficacy and safety expecially of anti‐VEGF therapy.