Abstract
A review of the pathology development and treatment of endometrial hyperplasia (carcinoma in situ) its relation to estrogen administration and its subsequent development into carcinoma is given. 3 clinical case reports illustrate the usual endometrial changes which occurred with continuous and prolonged use of progestational agents or n onsteroidal hormonal antagonists. Cystic and adenomatous hyperplasia gl ands regress and stroma can convert into decidua with treatment with progestational agents. Atypical endometria in menopausal or postmenopausal women may be converted into progestational endometria wit h these drugs but it is not considered a cure of carcinoma in situ.
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