Abstract
Injection of sclerosing solutions into the prostate for the treatment of benign prostatic hyperplasia (BPH) was reported early in the 20th century. Sclerosing solutions including phenol, glacial acetic acid, and glycerin were injected transperineally and were successful in four of nine patients reported by Broughton and Smith (1). However, this therapy was discontinued because of perineal pain occurring within minutes and lasting up to 24 hr in five of the nine patients. Broughton and Smith found extravasation of contrast medium in the region of the apex of the prostate in a patient who had undergone transperineal prostate injection. Transperineal injection of sclerosing solutions was associated with extraprostatic leakage and caused sphincter necrosis in three of seven canines in an animal study (2).
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