Abstract
To the Editor.— We have recently described our experience in treating patients with acquired immunodeficiency syndrome (AIDS) with transfer factor (TF) pooled from donors (healthy laboratory workers) and from homosexual men with serum antibodies to the human immunodeficiency virus (HIV) who had had stable lymphadenopathy for a period of more than one year. Administration of pooled TF resulted in the acquisition of skin test responses, improvement in lymphocyte blastogenesis, and increased natural killer cell activity. 1 We now report our preliminary experience using TF prepared from normal donors only. Study.— Transfer factor was prepared as previously described 1 from three healthy donors who had positive skin test responses to mumps and one who had positive skin test responses to both mumps and purified protein derivative. After informed consent was obtained, four patients with AIDS received weekly subcutaneous injections of 5 × 10 8 leukocyte equivalents of TF and were evaluated
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