Treatment of advanced seminoma with 3 cycles of etoposide-cisplatin chemotherapy (EP120): A single-centre retrospective cohort study.

Abstract

e16046Background: More than 95% of patients diagnosed with advanced seminoma are cured with chemotherapy - either 3 cycles of bleomycin (B), etoposide (E) and cisplatin (P) or 4 cycles of E-P. Radiotherapy can also be used for low-volume (Stage IIA-B) metastatic disease but may be associated with a higher risk of secondary malignancy. There is increasing emphasis on minimising late treatment toxicity in chemo-curable cancers. The optimal regimen to achieve long-term survival with minimal toxicity in advanced seminoma remains uncertain, in particular the value of bleomycin. Methods: Patients with advanced (Stage IIA and above) pure seminoma treated with etoposide 120mg/m2 days 1,2 and 3 and cisplatin 50mg/m2 day 1 and 2 (EP120) every 3 weeks for 3 cycles between the years 2000 and 2015 were retrospectively identified. Demographics, stage, clinical response, time of relapse, subsequent treatments and overall survival were recorded. Results: 117 patients were identified with a median age of 41years, and 15% ...