Abstract
report that antibiotics reduced “the time to reso-lution of symptoms and reduced the overall symp-tom burden” in children with acute otitis media, and they reject the null hypothesis on the basis of statistical benefit in three of four “primary” out-comes. There is no explanation of, or correction for, the use of four primary outcomes. The Con-solidated Standards of Reporting Trials recom-mend against more than one primary outcome because of “the problems of interpretation asso-ciated with multiplicity of analyses.”
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