Abstract
There are certain fundamental conceptions concerning acute laryngotracheobronchitis which to my mind should govern its management: Until there is more precise scientific information to the contrary, it appears to me to be reasonable to assume that this is not a specific disease entity but a clinical syndrome produced by a combination of factors, certain of which are man made. I believe it to be primarily a virus infection, 1 probably influenzal, with secondary invasion by various pathogens, most frequently the streptococcus, as is common in all virus infections of the respiratory tract. The most important pathologic change encountered in laryngotracheobronchitis is mucosal and submucosal inflammatory edema in the larynx and the lower respiratory tract. Its most urgent early symptoms are those of respiratory obstruction produced by the presence of edematous swelling in the subglottic space. Later symptoms of vast importance are those of respiratory obstruction from bronchial plugging, which I believe to be one
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