Abstract
In a previous paper (1) we proposed the thesis that acne is caused by a disturbance of the normal balance between androgens and estrogens. When the imbalance becomes such that there is a preponderance of the androgens the acnegenic action of the androgens which Hamilton (2) has demonstrated, is exerted. Iu support of this thesis we reported (1) the re suits of assays of androgens and estrogens in 33 female patients with acne. The results of the assays indicated significant androgen preponderance as compared to normal standards. No assay of urine from males was reported, for we were unable to obtain dependable estrone equivalent values from males. If this thesis concerning the cause of acne is correct, it should be possible to bring about the disappearance of the eruption by administering sufficient estrogen to restore the androgen-estrogen balance to normal, and males as well as females should respond to the treatment.
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