Abstract
<p>A large number of metabolic diseases are the cause of their particular violation. One of these conditions is a<br />violation of purine metabolism substances. Meaning of purine bases in metabolizme is large since they are part of<br />purine nucleotides forming the nucleid acid (DNA and RNA). Purine nucleotides also have a part-energy compounds<br />(ATP, ADP) and certain regulatory coenzymes monophosphate (cAMP, cGMP and others). Normal flow of purine<br />metabolism underlies the optimum level update nucleic acids and proteins, stability in energy metabolism. Violation<br />of the synthesis of purine nucleotides leads to decreased tissue growth. Uric acid (UA) is the end product of purine<br />metabolism substances. Level of UA, which is formed during the reaction hypoxanthine qsantinoqsidase reaction<br />is a marker of activity of free radical processes – endotoxicoses that trigger damaging processes in the vessels<br />and myocardium. Thus, the UA is the main derivative of purine metabolism and an important mediator of catabolic<br />processes in stress and cardiovascular disease. Most studies have confirmed the role of UA as a risk factor for<br />cardiovascular disease. In fact, it turned out that the UA stronger predictor of results than the ejection fraction or<br />the oxygen uptake. Uric acid can be inserted in the adhesion and aggregation of platelets. This gave birth to the<br />hypothesis that hyperuricemia increases the risk of coronary thrombosis. It is believed that the increase of the UA<br />displays endothelial damage. An important mechanism of rapid progression of CHF in elderly patients who have<br />suffered myocardial infarction, there are systemic activation of apoptosis – cell death. A correlation revealed a high<br />index values between apoptosis and severity of CHF. An interesting fact is, that the use of pentoxifylline, a corrector<br />of the purine metabolism in patients with CHF improves the left ventricular function and prognosis of patients. Correction<br />of purine metabolism then acts as a correction of endotoxemia and apoptosis.</p>
Highlights
A large number of metabolic diseases are the cause of their particular violation
of these conditions is a violation of purine metabolism substances
Meaning of purine bases in metabolizme is large since they are part of purine nucleotides forming the nucleid acid
Summary
Лікування шляхом корекції пуринового метаболізму при серцево-судинних захворюваннях у людей похилого віку Сечова кислота – головний дериват пуринового обміну і важливий медіатор катаболічних процесів при стресі та серцево-судинній патології. Важливим механізмом швидкого прогресування хронічної серцевої недостатності в пацієнтів похилого віку, які перенесли інфаркт міокарда, є системна активація апоптозу – програмованої клітинної загибелі.
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