Abstract
Severe aplastic anaemia is a marrow failure syndrome characterized by pancytopenia and hypocellular bone marrow.Immunosuppressive therapy(IST)consisting of antithymocyte or antilymphocyte globulin(ATG)and cyclosporine has been recommended for children lacking HLA-matched sibling donor.For children unresponsive to initial immunosuppressive therapy or those who relapsed after first immunosuppressive therapy, they can choose repeat course of immunosuppressive therapy, allogeneic hematopoietic stem cell transplantation, new drugs or clinical trials.And the prognosis has been greatly improved in recent years, dueing to the development of allogeneic hematopoietic stem cell transplantation and the application of new drugs such as eltrombopag.This article reviews researches advance in different therapies for children with relapsed or refractory severe aplastic anaemia, aimed at guaiding treatment methods. Key words: Severe aplastic anaemia; Children
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