Abstract
The knowledge for molecular mechanisms of preterm labor and preeclampsia is still premature. In the previous review, the author proposed that sex steroid treatment should be conserved for prospective clinical study in both preterm labor and preeclampsia. Unfortunately, little attention has been paid so far on the review article. Here, the authors present two cases of severe, complicated preeclampsia associated with preterm labor.
Highlights
Underlying mechanism of preeclampsia and onset of labor/preterm labor, despite progress in its research on molecular basis, need to be elucidated until effective treatments are established
Clinical effectiveness of P and 17-αhydroxyprogesterone capronate (17-P) in preterm labor remains under debate [7]
Alleviation of symptoms such as hypertension and uterine contraction were seen as the placental leucine aminopeptidase (P-LAP) and aminopeptidase A (APA) activities increased in maternal sera through advancing of gestation
Summary
Underlying mechanism of preeclampsia and onset of labor/preterm labor, despite progress in its research on molecular basis, need to be elucidated until effective treatments are established. Her pregnancy had been uneventful until week 22, at week 26, she was hospitalized due to severe preeclampsia (BP 190/108, proteinuria and edema) complicated with premature labor She was treated by intravenous drip injection of beta-2 agonist (ritodorine), and intramuscular injection of terbutaline (2 mg twice/day), in addition, with indomethacin (50 mg) to control uterine contraction. Fibrinogen levels kept constant throughout her pregnancy irrespective of the death of twin B (data not shown) APA activity levels in maternal sera continued at lower levels than mean normal pregnancy [2], a constant tendency toward increase with sex steroid treatment was observed (data not shown).
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