TREATMENT FOR NONPARASITIC LIVER CYST BY INTRACYSTIC INSTILLATIONS OF CARBON DIOXIDE AND MINOCYCLINE HYDROCHLORIDE UNDER ULTRASONICALLY GUIDED PUNCTURE

Abstract

In a past 3-year period 15 patients with nonparasitic large cysts were treated by intracystic instillation of carbon dioxide and/or minocycline hydrochloride under ultrsasonically guided puncture. Two of three patients treated with carbon dioxide obtained a shrinkage of the cyst more than 50% in the cyst reduction rate. But the remaining cyst which was over 18cm in diameter decreased in size by less than 25%. Three of four patients treated with minocyline hydrochloride obtained a cyst reduction rate of more than 50%. The remaining cyst decreased in size by less than 50%. Eight patients were treated with both minocycline hydrochloride and carbon dioxide, and a cyst reduction rate of more than 50% was recognized in seven of eight patients. There were no serious complications and the safety of the method was confirmed. It is concluded that the ultrasonically guided intracystic instillation of carbon dioxide and minocycline hydrochloride is more effective than single use of either of them; and can be an alternative to the absolute ethanol injection therapy.