Treatment for ASD patients with the cadherin and catenin complexes

Abstract

The cadherin and catenin complexes are responsible for refinements and proper neural circuit formation during thecritical period. Abnormal refinement causes deficiencies in spine pruning and neuronal disorders, including autismspectrum disorder. Autism spectrum disorder (ASD) is a developmental disorder caused by defects in the spinecompetition. An increase in the cadherin and catenin complex can simulate the synaptic signal transmission and increasecompetition to maintain average spine density. However, the proper neuronal function requires the elimination ofunnecessary spines. Therefore, this paper designs an experiment using an ocular dominance column in mice to evaluatewhether the cadherin and catenin complex can overcome the deficiencies in spine pruning for ASD mice and whetherspine pruning is correct. Then, the cadherin and catenin complex is adopted on PFC in mice to evaluate the effect ofcorrection on social behavior for ASD mice. This work proposes a better treatment for ASD patients using the cadherinand catenin complex