Treatment characteristics of chronic low back pain patients treated with buprenorphine buccal film or transdermal patch.

Abstract

Aims: Retrospective insurance claims analysis exploring treatment characteristics in chronic low back pain patients prescribed buprenorphine buccal film (Belbuca®) or transdermal patches. Patients and methods: The first buprenorphine prescription (buccal film or transdermal patch) was an index event. Patients were observed over 6month pre- and post-index periods. Propensity score matching minimized the selection bias. Results: Buccal film patients had a higher buprenorphine daily dose (501.7 vs 270.9 µg; p <0.001). The patch-to-film switching rate was higher than vice versa (11.5 vs 3.8%; p <0.001). The buccal film showed a greater reduction in opioid prescriptions (-1.1 vs -0.7; p =0.012), daily morphine milligram equivalents (-12.6 vs -7.3; p <0.001) and opioid treatment duration (-13.4 vs -7.6days; p =0.022). Conclusion: Buccal film was associated with higher buprenorphine doses and a greater reduction of opioid burden.